DescriptionRelatively little research has been conducted on improving adherence to treatment for Latino patients. Given the changing demands in the field of Latino mental health and the difficulties of treatment engagement and treatment retention with Latinos, finding effective mental health interventions is of utmost importance. The following study analyzes Motivational Interviewing (MI) techniques that have been used with depressed Latinos in an effort to increase their adherence to antidepressant medication and improve symptoms of depression. The analysis consists of a series of pragmatic case studies, which are intended to capture the contextual factors that contribute to either the success or failure of the MI intervention in facilitating medication compliance and that contribute to the manner in which psychological interventions can be adapted to special populations. The MI intervention involved two sessions delivered within a two-week time period and one booster session delivered approximately two months later. Throughout their participation in the study, participants were monitored with regard to their level of depression, motivation to adhere to their antidepressive medication treatment, and actual compliance in taking their antidepressant medication. In total, three subjects from the research study’s database were selected for case study analysis: one who was found to have a positive outcome, one who was found to have a negative outcome, and one who was found to have mixed results with the MI intervention. The results suggest that while Motivational Interviewing has the potential to work as a treatment-enhancing intervention, its success in producing behavioral change largely depends on how well the techniques are adjusted to the individual’s stage of change.