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Microfluidic continuous flow immunoassay for autonomous measurement of inflammation markers in a native sample stream
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Sasso, Lawrence A.. Microfluidic continuous flow immunoassay for autonomous measurement of inflammation markers in a native sample stream. Retrieved from https://doi.org/doi:10.7282/T3P849T2

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TitleMicrofluidic continuous flow immunoassay for autonomous measurement of inflammation markers in a native sample stream
NameSasso, Lawrence A. (author); Zahn, Jeffrey D (chair); Lee, KiBum (internal member); Androulakis, Ioannis (internal member); Undar, Akif (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2012
Other Date2012-05 (degree)
SubjectBiomedical Engineering, Microfluidic devices, Microfluidics
Extentxvii, 115 p. : ill.
DescriptionA microfluidic device is presented which fully automates all of the incubation steps of a microbead immunoassay. The device requires only controlled inlet flow rates to achieve this automation, and has no moving parts. These assays are useful for a wide variety of biomolecular quantification applications. Additional benefits of the micro-immunoassay are small sample volume requirements, high sampling rate capability, continuous monitoring, and the potential for real time monitoring of time-varying sample concentrations. The continuous monitoring feature has specific clinical applications such as studying the time course of inflammatory biomarkers in the blood during mechanical circulatory support procedures, and studying the inflammation response in cerebrospinal fluid following spinal cord injury. It has also been shown that multiplexed quantification on a single micro-immunoassay chip is possible. These unique features will enable a variety of new functionalities for clinical diagnostics and laboratory research as compared to existing assay techniques.
NotePh.D.
NoteIncludes bibliographical references
Noteby Lawrence A. Sasso Jr.
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3P849T2
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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