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Development of novel bimetallic chiral complexes & formation of cyclic aminals under under Friedländer conditions
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Mal, Rudajit. Development of novel bimetallic chiral complexes & formation of cyclic aminals under under Friedländer conditions. Retrieved from https://doi.org/doi:10.7282/T3TH8MSH

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TitleDevelopment of novel bimetallic chiral complexes & formation of cyclic aminals under under Friedländer conditions
NameMal, Rudajit (author); Seidel, Daniel (chair); Knapp, Spencer (internal member); Hultzsch, Kai (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2010
Other Date2010 (degree)
SubjectChemistry and Chemical Biology, Ligands (Biochemistry)
Extentix, 74 p. : ill.
DescriptionThe design of new chiral binuclear ligands was undertaken to address the challenge of catalyzing nucleophilic additions to simple α,β- unsaturated carbonyl compounds. The designs were based on natural bimetallic enzymes as well as on synthetic achiral bimetallic complexes. Ligands with different electronic and structural properties were synthesized and a variety of transition metal complexes prepared. Their catalytic activities were tested in 1,4-additions of indole to α,β-unsaturated carbonyl compounds. Single X-ray crystallography was used to gain an insight into the nature of these newly developed chiral bimetallic complexes. Efforts were made to synthesize chiral bimetallic complexes derived from amino indanol.
A new reaction methodology was investigated to form cyclic aminals from aminobenzaldehydes and secondary amines. The methodology was shown to be successful for broad range of substrates. L-proline could be used in place of secondary amines in a decarboxylative variant of the reaction. The use of microwave irradiation was explored as a means to extend the scope of this methodology.
NoteM.S.T.
NoteIncludes abstract
NoteIncludes bibliographical references
Noteby Rudrajit Mal
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3TH8MSH
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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